Less painful to inject
Norditropin® somatropin contains histidine and phenol – the least painful buffer and preservative composition.3
Preservatives
It has been proven that growth hormone formulations with m-cresol are more painful than formulations with benzyl alcohol, and there is no difference between formulations with benzyl alcohol and formulations with phenol.3
Buffers
Injection with histidine-containing solvent has been shown to be less painful than citrate-buffered solvents.3
Comparison of injection pain following subcutaneous injection of histidine (H)- and citrate (C)-buffered solvents. Injections were performed in pairs and subjects evaluated whether one of the injections was more or less painful than the other. H >> C = much more discomfort; H > C = more discomfort; H = C = no difference; H < C = less discomfort; H << C = much less discomfort.3
The NordiPen® device is less painful to inject
Because Norditropin® somatropin contains a histidine and phenol composition, they result in less injection pain than other growth hormone products.3
Comparison of buffer and preservative composition of different GH products for subcutaneous injection.3
