Less painful to inject
The Norditropin NordiFlex® pen contains histidine and phenol – the least painful buffer and preservative composition.5
Preservatives
It has been proven that growth hormone formulations with m-cresol are more painful than formulations with benzyl alcohol, and there is no difference between formulations with benzyl alcohol and formulations with phenol.5
Buffers
Injection with histidine-containing solvent has been shown to be less painful than citrate-buffered solvents.5
Comparison of injection pain following subcutaneous injection of histidine (H)- and citrate (C)-buffered solvents. Injections were performed in pairs and subjects evaluated whether one of the injections was more or less painful than the other. H >> C = much more discomfort; H > C = more discomfort; H = C = no difference; H < C = less discomfort; H << C = much less discomfort.5
The Norditropin NordiFlex® pen is less painful to inject
Because the Norditropin NordiFlex® pen contains a histidine and phenol composition, it results in less injection pain than other growth hormone products.5
Comparison of buffer and preservative composition of different GH products for subcutaneous injection.5
